Frequently asked question: How is the formation of sickle cells triggered?

The development of sickle cells is influenced by changes in the amount of oxygen in the blood and the pH level of the blood, as well as by changes to the concentration of osmotic agents in the blood (osmolarity).
These factors change in cases of fever, infection, cold environment, or pain, as well as when someone is at high altitude (such as in the mountains), dehydrated, or suffers from (physical) stress. It is therefore very important to prevent and avoid such circumstances as much as possible.

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