Frequently asked question: When do the first symptoms of sickle cell disease appear?

Since newborns still mainly have fetal hemoglobin (HbF), they will not have any sickle cell disease symptoms when the neonatal screening test is conducted. Newborns do, however, already produce small quantities of HbS. The neonatal screening test will reveal HbS production and this will lead to the diagnosis of sickle cell disease. Over the first months of a child’s life, HbS production will increase, topping out between the 4th and the 6th month. From that moment onwards, sickle cell disease symptoms may start to occur.

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Frequently asked question: When do the first symptoms of sickle cell disease appear?

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