Frequently asked question: What effect does a blood transfusion have on sickle cell disease?

A blood transfusion or an exchange transfusion will (temporarily) reduce the HbSS red blood cell count or other sickle cell red blood cell counts. And it will (temporarily) boost the blood’s ability to transport oxygen through the healthy red blood cells introduced into your bloodstream by the blood transfusion. Blood transfusions are indicated only in cases of severe symptoms.

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